University of Florida
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied but may be responsible for persistent systemic inflammation clinically observed in surgical intensive care patients. Therefore, the objective of this project is to investigate the oral and gut microbiome after the acute phase of sepsis, severe trauma injury, cardiopulmonary bypass, and major vascular surgery to compare with 108 age-matched healthy population controls
The investigators hypothesize that alterations of the oral and gut microbiota will correlate with persistent systemic inflammation in surgical intensive care unit survivors compared to existing healthy population controls. This research group will collect oral and stool samples from 108 sepsis survivors, 108 trauma survivors, 108 cardiopulmonary bypass survivors, and major vascular surgery survivors (groups of ages 18-45, 46-64, and \>65; male and female; n=18 per age + sex cohort) admitted to the surgical intensive care unit between day 7 and 28 of hospital admission, as well as 3 and 6 month…
Sepsis Population Inclusion Criteria 1. Admission to the 46, 77, 87, 4 East, 4 West, or 24-5 ICUs where clinical care can be managed by the critical care organization guided by standard operating procedures. 2. Age ≥18 years 3. Meets Sepsis 3 criteria at time of sepsis diagnosis 4. Has remained in ICU for 14 days (+/- 7 days) following sepsis diagnosis. 5. Ability to obtain patient/LAR informed consent. 6. Is receiving adequate nutritional intake: oral or enteral nutrition. Exclusion Criteria 1. Severe traumatic brain injury with unencumbered assessment of GCS equaling 3 on admission to in…
Oral swab and saliva, human feces collection and blood sampling
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