Massachusetts General Hospital
The goal of this study is to examine how whole-body hyperthermia affects the thermoinflammatory profile, which includes the combined immune and heat shock response, in patients with depression and whether these changes correlate with decreased depression in individuals with Major Depressive Disorder.
The study is a maximum of 42-day randomized controlled trial (RCT) of Whole Body Hyperthermia (WBH) vs. Sham for subjects with depressive symptoms at the Depression Clinical Research Program (DCRP) at Massachusetts General Hospital (MGH). 60 subjects with Major Depressive Disorder (MDD), males and females, between the ages of 18 and 65 years will be recruited and undergo a screening visit prior to being randomized to receive a single treatment of WBH or sham. The primary endpoint will be measurement of Interleukin-6 (IL-6) and other inflammation associated proteins (cytokines and heat shock pr…
Inclusion Criteria: 1. Females and Males ages 18-65 2. English language proficiency 3. Ability to provide informed consent 4. Have a current primary psychiatric diagnosis of major depressive disorder (MDD) of at least 4 weeks duration, as defined by Diagnostic \& Statistical Manual, 5th Edition (DSM-5) criteria using the MINI. 5. Score of ≥ 24 on the Inventory of Depressive Symptomatology - Clinician Rated (IDS-CR) 6. Individuals of childbearing potential must use an acceptable form of birth control. Exclusion Criteria: 1. Pregnancy or planned pregnancy during study 2. Current breastfeeding…
Hyperthermia exposure using Heckel Hyperthermia Device
Sham (mild heating) using Heckel Hyperthermia Device
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