Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix
Virginia Polytechnic Institute and State University
Summary
This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.
Description
This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.
Eligibility
- Age range
- 25–50 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games. Exclusion Criteria: * history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI
Interventions
- Behavioralcognitive behavioral therapy
cognitive behavioral therapy
- Behavioralvaluation with instruction
repeat laboratory sessions of computerized learning game
- Behavioralvaluation without instruction
repeat laboratory sessions of computerized learning game
Location
- Fralin Biomedical Research Institute at Virginia Tech CarilionRoanoke, Virginia