Feasibility Study of Lung Cancer Screening Using Cell-Free DNA Liquid Biopsy at Home in High-Risk Current and Former Smokers
City of Hope Medical Center
Summary
This clinical trial investigates how practical and doable (feasibility) cell-free deoxyribonucleic acid (DNA) liquid biopsy is in screening high-risk patients for lung cancer. Currently, a low dose computed tomography (CT) scan is used to screen for lung cancer, however, due to various factors, few high-risk patients are screened. Liquid biopsy utilizes technology that can detect small amounts of DNA shed by cancer cells and may be able to spot lung cancer at an earlier stage. If a positive result comes back from the liquid biopsy, a patient may be more willing to get a low dose CT (LDCT) scan, possibly confirming the biopsy's findings and thus leading to more early lung cancer detection.
Description
PRIMARY OBJECTIVE: I. To determine the feasibility of lung cancer screening using liquid biopsy in a community setting. SECONDARY OBJECTIVES: I. To determine screening follow-through rates in those who agreed to undergo screening by preferred modality (liquid biopsy versus \[vs\] LDCT). II. To determine the rate of LDCT following liquid biopsy (in those who underwent liquid biopsy) after stratifying by test result (negative versus positive). III. To compare participant sociodemographic factors (age, sex, race/ethnicity, educational background) and survey scores across screening preference…
Eligibility
- Age range
- 50–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Documented written informed consent of the participant. * Age 50-80 years. * Smoking history of \>= 20 pack-years and if quit, quit within 15 years. * Received referral for counseling for lung cancer screening and would qualify for LDCT. * Health Insurance that will pay for a LDCT for lung cancer screening at either City of Hope Duarte, Newport Beach (Newport Diagnostic Imaging), or Lancaster (Renaissance Imaging/Antelope Valley Outpatient Imaging Center). * Willingness to provide blood sample. * English speaking. * Consent to undergo lung cancer screening with either li…
Interventions
- ProcedureLiquid Biopsy
Undergo liquid biopsy
- ProcedureLow Dose Computed Tomography of the Chest
Undergo low dose CT
- OtherSurvey Administration
Ancillary studies
Location
- City of Hope Medical CenterDuarte, California