MicroRNA Regulation of Chronic Inflammation During Aging
University of Utah
Summary
This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation. The enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \& exercise tests.
Description
We will recruit healthy, non-obese (\<30kg/m2 BMI) younger (N=20; 18-35y) and older (N=20; \>65y) male and female participants (as determined by sample size calculation) in the Salt Lake City area. 1. VISIT 1 (Screening, visit duration: 1 hour): Once the participant is identified, they will be scheduled for a screening visit at the CTSI (421 Wakara Way) to see if they meet incl/excl criteria and to sign an informed consent document. As part of the visit, Upon arrival, we will gather basic health information such as height, weight, blood pressure, and heart rate. * Participant will undergo…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Age between 18 - 35y; 65y and older 2. BMI: \<30 kg/m2 3. Ability to sign informed consent 4. For older participant group: Clinical Frailty Scale score \< 3 and Mini-Cog score \> 3 5. Good general medical health, ambulatory and in independent living setting Exclusion Criteria: * History of cardiovascular disease (e.g., CHF, CAD, MI, CVA) * History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted) * History of kidney disease or failure (CKD \> stage 4) * History of vascular di…
Location
- The University of UtahSalt Lake City, Utah