Prandial Metabolic Phenotype in Adults
Texas A&M University
Summary
Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab developed a pulse method combining multiple stable isotopes to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, the investigators may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with special interest in metabolism of amino acids as they have been associated with aging-related disorders.
Description
The study involves 1 screening visits of approximately 3 hours and 6 study days of approximately 8 hours. Subjects will be asked to arrive in the fasted state on all study days. Fasting prior to screening is not required. On the screening day, body weight, height, and body composition by Dual-energy X-ray absorptiometry (DXA) will be measured. In addition, The Six-Minute Walk Test (6MWT) and skeletal muscle function tests will be assessed at the end of each screening visit. Each study visit will begin with vital signs. Before administration of the feeding or the tracer solution, baseline blo…
Eligibility
- Age range
- 60–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age: 60-80, inclusive * Stable body-weight (± 5%) for the past 3 months * Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations. * Ability to walk, sit down and stand up independently or with walking mobility aids * Ability to lie in supine or elevated position for up to 7 hours * Willingness and ability to comply with the protocol Exclusion Criteria: * Established diagnosis of current malignancy * History of untreated metabolic diseases including hepatic or renal disorder * Presence of acute…
Interventions
- Dietary SupplementTotal Amino Acids
Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Alanine, Arginine, Aspartate, Cystine, Glutamine, Glutamate, Glycine, Proline, Serine, Tyrosine. All supplements are commercially available.
- Dietary SupplementEssential Amino Acids
Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.
- Dietary SupplementEssential Amino Acids + Hydroxy-methylbutyric acid (HMB)
Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, HMB. All supplements are commercially available.
- Dietary SupplementEssential Amino Acids + Leucine
Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Extra leucine. All supplements are commercially available.
- Dietary SupplementEssential Amino Acids High
Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine. All supplements are commercially available.
Location
- Human Clinical Research FacilityCollege Station, Texas