Prevention of Age-associated Cardiac and Vascular Dysfunction Through Nrf2 Signaling Using the Nutritional Supplement Sulforaphane
Texas Tech University Health Sciences Center
Summary
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, and exercise endurance at 0 and 24 weeks. Peripheral blood cells from treated and control subjects will be compared for mitochondrial respiratory function, oxidative damage, pro-inflammatory cytokines, and expression of antioxidant \& anti-electrophile genes.
Description
Study Design: We intend to include 200 individuals (100 men and 100 women, ≥60 years), with a diagnosis of heart failure with preserved ejection fraction (HFpEF) who are able to walk at least 500 feet, to participate in a randomized controlled, double blinded study, with Sulforaphane (SFN) or placebo treatment for 24 weeks. These potential subjects will be recruited in a randomized, controlled, double blinded pilot study comparing SFN to placebo. The study will be conducted at the Texas Tech University Health Sciences Center, and University Medical Center. The trial is approved by our local IR…
Eligibility
- Age range
- 60–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age \> 60 years * Diagnosis of HFpEF (HF symptoms with a normal EF (\>/=50 %) * Ability to walk more than 500 feet (by self-report) * Willing to avoid taking all over the counter antioxidant phytochemical supplements (vegetable or fruit-containing supplement pills) during the study Exclusion Criteria: * Inability to provide informed consent * Diagnosis of active cancer * Inability to read and understand the SF-36 in English * Participants using over the counter antioxidant supplements * Participants with pulmonary or other issues which restrict walking capacity * On ox…
Interventions
- DrugSulforaphane
Caplets containing SFN-rich broccoli sprout extracts or placebo caplets containing microcrystalline cellulose will be obtained from from Nutramax Labs.
Location
- Texas Tech University Health Sciences Center (TTUHSC)Lubbock, Texas