Perioperative Stress Reduction in Ovarian Cancer (PRESERVE Trial)-A Prospective Randomized Pilot Study

Summary

The purpose of this study is to see if propranolol and etodolac along with mind-body resilience training/MBRT and music therapy help participants who are experiencing physiological stress before, during, and after primary debulking surgery/PDS or IDS and also if it's better than the standard-of-care approach (no intervention for reducing stress).

Eligibility

Age range

18+ years

Sex

Female

Healthy volunteers

No

Interventions

• Behavioral
  Mind-body resilience training

  MBRT is a meditation technique used to achieve relaxation)

• Behavioral
  Music therapy

  Music listening was found, in multiple trials, to significantly reduce self-reported anxiety, physiologic indicators of anxiety, and/or sedation requirements

• Drug
  Propranolol

  Propranolol 20 mg PO BID (for 21 consecutive days), Propranolol 10mg PO BID (for 3 consecutive days POD 14-16)

• Drug
  Etodolac

  Etodolac 400 mg PO BID (for 21 consecutive days)

Locations (7)