Randomized Controlled Trial of Preoperative Corticosteroids in Autoimmune ThyroidDisease

Indiana University

Summary

This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.

Eligibility

Age range: 18+ years
Sex: All
Healthy volunteers: No

Detailed criteria

* Inclusion Criteria: ■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease. * Exclusion Criteria: * Pediatric patients \< 18 * Prior treatment with RAI * Prior neck surgeries * Known diagnosis of thyroid cancer * Diabetic patients on medications * A history of adverse reactions to corticosteroids. * Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of…

Interventions

Drug
Dexamethasone
Will take Dexamethasone pre-operatively
Drug
Placebo
Will take Placebo pre-operatively

Locations (3)

IU Health North Hospital
Indianapolis, Indiana
IU Health Methodist Hospital
Indianapolis, Indiana
IU Health University Hospital
Indianapolis, Indiana

Randomized Controlled Trial of Preoperative Corticosteroids in Autoimmune ThyroidDisease

Summary

Eligibility

Interventions

Locations (3)

Run this study?

Details

Conditions