Randomized Controlled Trial of Preoperative Corticosteroids in Autoimmune ThyroidDisease
Indiana University
Summary
This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
* Inclusion Criteria: ■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease. * Exclusion Criteria: * Pediatric patients \< 18 * Prior treatment with RAI * Prior neck surgeries * Known diagnosis of thyroid cancer * Diabetic patients on medications * A history of adverse reactions to corticosteroids. * Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of…
Interventions
- DrugDexamethasone
Will take Dexamethasone pre-operatively
- DrugPlacebo
Will take Placebo pre-operatively
Locations (3)
- IU Health North HospitalIndianapolis, Indiana
- IU Health Methodist HospitalIndianapolis, Indiana
- IU Health University HospitalIndianapolis, Indiana