Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
University of Alabama at Birmingham
Summary
This study is dedicated to help identify biomarkers for depression and suicide. The purpose of the study is to better understand these links to improve medical and psychiatric care in the future. This research is also to test the effects of standard treatment of depression on improvement in depressive and suicidal behavior and on biomarkers (e.g. miRNA) for these disorders.
Eligibility
- Age range
- 10–24 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: All participants: 1. Physically healthy 2. willing and able to provide informed consent (if under 18 also parent or guardian consent) MDD participants: 1. A definite diagnosis of DSM-5 2. a Children's Depression Rating Scale-Revised (CDRS-R) score \>=30. Suicidal ideation participants: Columbia Suicide Severity Rating Scale (C-SSRS) score \>=4 rated over the last two weeks. Suicide attempt group: 1\. Participants will have had an attempt in the previous two weeks that is serious enough to require medical attention and shows evidence of at least a medium level of inten…
Interventions
- GeneticGenetic testing
Attempting to identify the genetic biomarker that can identify risk for suicidal ideation and action
Locations (2)
- University of Alabama at BirminghamBirmingham, Alabama
- UAB Huntsville Regional Medical CampusHuntsville, Alabama