Decoding and Modulating Affective Brain States
University of Pennsylvania
Summary
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.
Description
The study involves 11 visits over approximately 10 weeks, depending on scanner availability and scheduling. See below for the study schedule with a summary of the procedures: * Visit 1: Screening Procedures (\~3-4 hours). The first part of the screening will take place remotely (\~1 hour). The investigators will begin by reviewing the Informed Consent Form (ICF). Participants who agree to participate and sign the ICF will then complete several questionnaires. Those who meet preliminary eligibility criteria based on the remote procedures will be invited for an in-person visit. The in-person sc…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion criteria: 1. 18-65 years old 2. Patient Health Questionnaire (PHQ-9 score) = or \> than 10 3. Comprehension of instructions in the English language. 4. Capacity to provide informed consent and follow study procedures. 5. Availability for the duration of the study. Exclusion Criteria: 1. Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder 2. Recent use of psychoactive medications or substances as determined by investigators 3. History of neurological disorder or traumatic brain injury (other than mild) 4. Unable to have an MRI scan, or curren…
Interventions
- DeviceTranscranial Magnetic Stimulation
Transcranial Magnetic Stimulation (TMS) is a non-invasive form of brain stimulation. TMS can influence activity in various brain regions, and it allows researchers to test or modify brain circuit communication. The MagPro X100\* magnetic stimulator and Cool-B65 Butterfly Coil are FDA-approved for rTMS treatments of depression.
Location
- University of PennsylvaniaPhiladelphia, Pennsylvania