Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals With Neurodegenerative Disease
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Summary
The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.
Description
This study will inform clinicians in quantitatively assessing baseline disease severity, selectively applying the appropriate exercise to the disease pathology, and measuring efficacy of the exercise intervention. As part of this overall goal, the aims are to: A. Determine feasibility of remotely supervised exercise programs. B. Optimize remote outcome measures for clinical monitoring and towards future clinical trials. C. Measure changes in balance and walking post intervention.
Eligibility
- Age range
- 5–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing. * The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis. * The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis. * For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be…
Interventions
- BehavioralHome exercise
Exercise to address limitations impacting walking
Location
- Kennedy Krieger InstituteBaltimore, Maryland