Oral Cannabidiol for Tobacco Cessation
Johns Hopkins University
Summary
Cannabidiol is a compound found in cannabis plants that is well tolerated, has low abuse liability, and might be an effective medication to promote tobacco cessation. This clinical study will use a validated approach for screening tobacco cessation medications to determine if oral cannabidiol increases short-term tobacco abstinence, and evaluate mechanisms that might explain how cannabidiol alters smoking behavior. Results from this study will provide data on the therapeutic potential of cannabidiol for tobacco cessation.
Description
Although tobacco smoking rates continue to decrease, cigarette smoking remains the leading cause of preventable disease and death in the United States and few tobacco users achieve sustained abstinence, underscoring the need for alternative treatments. The endocannabinoid system can modulate the reinforcing effects of nicotine and may be a target for development of pharmacotherapies for tobacco cessation. The cannabinoid type 1 receptor receptor inverse agonist/antagonist rimonabant has demonstrated efficacy in increasing tobacco abstinence rates in clinical trials, though it was abandoned as…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Have provided written informed consent 2. Be between the ages of 18 and 65 3. Report use of \> 10 cigarettes per day for \> 1 year with smoking status verified by either a positive breath carbon monoxide test (\>8ppm) or urine cotinine test (\>200ng/mL) at screening 4. Report interest in quitting tobacco in the next two months 5. Are willing to engage in a series of practice quit attempts as part of the study. 6. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests as determined by a licensed medica…
Interventions
- Drug300 mg Cannabidiol
300 mg CBD in Medium Chain Triglyceride oil b.i.d.
- Drug600 mg Cannabidiol
600 mg CBD in Medium Chain Triglyceride oil b.i.d.
- DrugPlacebo
Medium Chain Triglyceride oil
Location
- Johns Hopkins Behavioral Pharmacology Research UnitBaltimore, Maryland