The Impact of Upper Gastrointestinal Dysmotility on Aspiration-associated Symptoms
Boston Children's Hospital
Summary
The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment. The investigators are conducting a ten week cross over study comparing prucalopride to famotidine for the treatment of aspiration-associated symptoms.
Eligibility
- Age range
- 5–21 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. are 5-21 years of age; 2. receive \>90% of their calories by enteral tube (i.e., patients take no food or drink by mouth); 3. are determined to be at high risk for aspiration pneumonia based on evidence of impaired airway protective mechanisms, documented by aspiration on video fluoroscopic swallow study; 4. have static neurologic impairment, defined as functional and/or intellectual impairment that results from a chronic neurologic or related diagnosis (e.g., cerebral palsy) with no prospect of progression for at least one year; 5. have chronic respiratory symptoms, de…
Interventions
- DrugPrucalopride
Prucalopride 0.04 mg/kg/day
- DrugFamotidine
Famotidine 0.4 mg/kg/day
Location
- Boston Children's HospitalBoston, Massachusetts