Multiomic Diagnostics in Child and Adolescent Psychosis
Rady Pediatric Genomics & Systems Medicine Institute
Summary
Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of psychosis and impact care. The investigator also hopes to identify new genetic and/or autoimmune causes of psychosis that may inform new treatment for future patients.
Description
Schizophrenia is a severe mental illness that often starts in late adolescence or early adulthood where individuals experience changes in how they perceive and interact with the world around them (psychosis). These extreme changes in how one perceives and interacts with the world can cause great distress and have a very negative impact on one's life. In most cases, the cause of schizophrenia or psychosis is unknown. However, in a small subset of people who develop schizophrenia or psychosis, their own immune system creates antibodies that attack the brain, which leads to psychosis (autoimmune…
Eligibility
- Age range
- 7–17 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Individual in whom one of the following criteria is met: 1. Child/adolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis OR 2. Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant. Exclusion Criteria: Child/Adolescent patients who do not meet any of the inclusion criteria, or those who: 1. Already received any prior whole genome sequencing or exome sequencing. 2. Un…
Interventions
- GeneticGenetic: Genomic sequencing and molecular diagnostic results, if any.
Genomic sequencing results may be used for diagnosis and treatment of participants.
- Diagnostic TestPhage display ImmunoPrecipiation Sequencing (PhIP-Seq)
Whole Proteome programmable phage display immunoprecipitation sequencing will be used to diagnose known and novel autoantibodies.
Location
- Rady Children's Hospital San DiegoSan Diego, California