An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression
Singula Institute
Summary
This research study is studying how thoughts, feelings, surroundings, and individual biology may contribute to why and how people experience anxiety or depression. We are trying to find out the wide variety of reasons that people may experience anxiety or depression, and why different people are helped by different forms of treatment. We are trying to determine why people stay in treatment, and what factors contribute to a positive or negative response to treatment. These reasons may be due to thoughts, feelings, beliefs, personality, biology, social support network, life events, and barriers to treatment. A wide range of information about factors that impact anxiety and depression will be included. These include, among others, measures of inflammation, hormone levels, behavior, spoken language, personality, medical history, social determinants of health, and attitudes toward mental health and its treatment. The study involves psychological and psychiatric treatments in the form of psychotherapy and medication management. The participant will be asked to set specific goals for study treatment, and to provide videos between sessions about relevant medication, emotional, and sleep factors in their life. In summary, this study will collect biological, psychological, and social factors that may play a role in anxiety and depression. This will inform both individual's diagnosis and treatment and will be used in a later set of analyses that can inform diagnosis and treatment for other individuals who share similar characteristics.
Description
A Biopsychosocial Approach to Diagnosing and Treating AD and MDD in a Learning Health System Biochemically-mediated changes related to the stress response and immune system may selectively impact susceptible brain regions or functional networks that correspond with many of the cognitive functions that are often affected clinically during depressive episodes \[1, 2\]. Although MRI-based studies have paved a path toward biological validation of Major Depressive Disorder (MDD), particularly in large-scale studies that have shown promise to detect biological subgroups \[3\], financially prohibiti…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * 18 to 65 years of age. * Each subject must have a level of understanding sufficient to agree to all required tests and examinations and sign an informed consent document. * At the initial study enrollment, subjects must have fulfilled DSM-5 criteria for Major Depression, single episode or recurrent. * At the initial study enrollment, subjects may have fulfilled DSM-5 criteria for an Anxiety Disorder Comorbid Psychiatric Disorders, specifically Anxiety Disorders (Panic Disorder, Specific Phobia, Social Anxiety Disorder, Generalized Anxiety Disorder), Obsessive Compulsive…
Location
- Singula Institute, 353 Lexington Avenue (Room 600)New York, New York