Understanding Mental Health Crises in Youth With Intellectual and Developmental Disabilities
Rady Pediatric Genomics & Systems Medicine Institute
Summary
This study is an unmatched, case-control study of 150 youth (Ages 7-17) with a parent reported Intellectual Developmental Disability (IDD) who present to Rady Children's Hospital Emergency Department with a Mental Health Crisis (MHC). Rady Children's Institute for Genomic Medicine (RCIGM) will collect biological samples (such as blood) of these participants to study their genomes, medical and psychiatric profiles to better understand specific characteristics that may predispose them to MHC's. The 150 youth will be compared to historical, publicly available cohorts of youth with IDD's
Description
Approximately 7 million youth in the US have intellectual and developmental disabilities (IDDs) and about 10% of youth with IDDs are admitted to hospitals due to a mental health crisis (MHC) each year. With insufficient community services to support youth with IDDs and less than half of US mental health facilities providing services for them, emergency departments (EDs) have boarding rates for children with IDDs 2-3 times higher than peers without IDDs, part of a national youth mental health crisis. There is a critical need to identify youth with IDDs at risk for MHCs prior to onset. Machine-l…
Eligibility
- Age range
- 7–17 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Child/adolescents admitted to the RCHSD ED with an IDD presenting in a MHC that includes, but is not limited to: * Aggression towards others * Severe agitation * Self-injury * Elopement OR Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. (Family members are eligible for participation in this study if they presumed genetically related to a participant). Exclusion Criteria: Child/Adolescents participants who do not meet any of the inclusion criteria, or those who: * Already received any prior whole genome sequencing or e…
Interventions
- GeneticGenomic sequencing and molecular diagnostic results, if any.
Genomic sequencing results may be used for diagnosis and treatment of participants.
- OtherEHR-Based Network Model
EHR-based network will be created to predict psychiatric outcomes in youth with IDDs
Location
- Rady Children's Hospital San DiegoSan Diego, California