Adverse Outcomes and Mortality in Liver Transplant
Mayo Clinic
Summary
Prospective natural history pilot study to explore the link between muscle composition using an MRI-based Muscle Assessment Score (MAsS) and adverse outcomes in liver transplant candidates.
Description
Sarcopenia, characterized by the progressive loss of muscle volume and function, is a common and major complication in end-stage liver disease which significantly contributes to adverse outcomes and mortality as well as hampers successful outcomes for treatments such as liver transplant (LT). High resolution image-based techniques have been instrumental in furthering our understanding of body composition in sarcopenia specifically and human health in general. While several methods exist to evaluate body composition, imaging techniques, such as computed tomography (CT) and magnetic resonance im…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. All patients with end-stage liver disease undergoing evaluation for liver transplantation 2. Patient clinically indicated for MRI during transplant candidacy evaluation 3. Adult Exclusion Criteria: 1\. Contra indication to MRI
Interventions
- Diagnostic TestMAsS
Add MAsS to standard of care MRI scan
Location
- Mayo Clinic ArizonaPhoenix, Arizona