Effects of NAD Restoration on Neurovascular Coupling in Community Dwelling Older Adults
University of Oklahoma
Summary
Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.
Description
This study is designed to test the hypothesis that restoration of Nicotinamide Adenine Dinucleotide (NAD) levels with Nicotinamide Riboside (NR) in older adults will improve neurovascular coupling (NVC) responses and micro- and macrovascular endothelial function. This hypothesis will be tested by assessing the effects of treatment with oral NR (1g/day per os for 8 weeks) or placebo (8 weeks) in community dwelling older adults (60-85 years of age).
Eligibility
- Age range
- 60–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age ≥60 and ≤85 years of age * Adequate hearing and visual acuity to participate in the examinations * Ability to read and write in English * Competence to provide informed consent. * Mini-Mental State Exam score ≥24 Exclusion Criteria: * Vision or hearing impairment that would impair the ability to complete study assessments * Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer * Cerebrovascular accident other than TIA within 60 days prior to Visit 0 * Major psychiatric disease, including major depression not currently controlle…
Interventions
- DrugNicotinamide riboside
Oral NR, 1g/day per os for 8 weeks
- DrugPlacebo
Visually identical pill to NR, daily per os for 8 weeks
Location
- University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma