Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy

Summary

Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

No

Interventions

• Other
  PS and OS stimulation order 1

  PS, OS, OS

• Other
  PS and OS stimulation order 2

  OS, PS, OS

• Other
  PS and OS stimulation order 3

  OS, OS, PS

Location