Sex Selection of Human Spermatozoa
Weill Medical College of Cornell University
Summary
This study aims to demonstrate a reliable method of selecting gender specific sperm. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient layers. The selected gender specimen will then be utilized for assisted reproductive fertilization- in vitro fertilization or intrauterine insemination which are routine standard of care procedures.
Description
The study aim is to test a simple, reliable, and inexpensive method to attempt selection of gender specific spermatozoa. Couples will undergo evaluation and treatment according to the standard clinic procedures. Sperm samples provided for infertility treatment will be further analyzed routine semen analysis for volume, concentration, mobility and morphology. Sperm samples will be provided by consenting males undergoing infertility treatment. A multilayer density gradient will be performed utilizing an FDA approved solution, Enhance-S Plus Cell Isolation Media (Vitrolife, San Diego, CA). This…
Eligibility
- Age range
- 18–89 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Couples undergoing infertility treatment with IVF or insemination seeking gender specific offspring for medical and non medical reasons Exclusion Criteria: * Severe male factor
Interventions
- ProcedureSperm Sorting
Selection of gender specific spermatozoa using a multilayer density gradient solution
Location
- Center for Reproductive Medicine- Weill Cornell MedicineNew York, New York