Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application
Indiana University
Summary
Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia (ADLD). Participants will undergo Deep Brain Stimulation surgery to treat laryngeal dystonia as part of their clinical care. Before surgery, as part of the study they will have specialized testing to study the movement of the vocal cords, as well as functional magnetic resonance imaging (fMRI). While in the operating room, researchers will examine brain waves to better understand how faulty brain firing patterns lead to dystonia. After surgery, and activation of the deep brain stimulator, participants will repeat speech testing and vocal cord imaging as well as magnetic resonance imaging (MRI).
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients with ADLD and ADLD plus tremor, as diagnosed by routine clinical examination by laryngologist, speech language pathologist, and neurologist. * Patients undergoing globus pallidus interna (GPi) deep brain stimulation (DBS) for ADLD with tremor * Age range of 18-80 years * Native speakers of American English will be recruited since there are known differences in voice and neural signals of native and non-native speakers * No evidence for dementia as assessed by neurologist. * No evidence for severe untreated mood disorder as assessed by neurologist, or as evident…
Interventions
- DeviceDeep Brain Stimulation
Deep Brain Stimulation of Globus Pallidus interna
Location
- Indiana UniversityIndianapolis, Indiana