University of Miami
The purpose of this research is to determine whether the combination of selinexor, venetoclax, and dexamethasone therapy can increase anti-cancer effects in patients with translocation 11;14-positive (t(11;14)), relapsed/refractory myeloma (RRMM).
Inclusion Criteria: 1. Patients must have a documented diagnosis of multiple myeloma defined by the International Myeloma Working Group Criteria (IMWG).5 Patients at initial diagnosis must have had a serum M-protein ≥ 3 g/dL and/or bone marrow plasma cells ≥10%, and at least one of the following: 1. Anemia: Hemoglobin ≤10 g/dL, or 2. Renal failure: serum creatinine ≥ 2.0 mg/dL, or 3. Hypercalcemia: Ca ≥10.5 mg/dL, or 4. Lytic bone lesions on X-ray, CT, or Positron emission tomography/Computed Tomography (PET/CT), or 5. ≥ 2 focal lesions on spinal magnetic resonance imaging (MR…
Selinexor tablets will be administered orally (PO) once per day at assigned dosage and frequency per protocol.
Venetoclax tablets will be administered orally (PO) once per day at assigned dosage and frequency per protocol.
Dexamethasone tablets will be administered orally (PO) once per day at assigned dosage and frequency per protocol.
Arctuva estimate
Verify or correct the compensation shown for this listing.