University of California, Los Angeles
This randomized controlled trial will test whether a recently developed community-based intergenerational mentoring program known as Generation Xchange (GenX) can enhance antiviral resistance in older African-American women and men in a low-SES urban community. Additional studies will identify the biological processes that promote resistance to respiratory virus infections and viral disease in older African-American women and men.
This randomized controlled intervention trial (planned n=160) will test whether participation in the Generation Xchange (GenX) intergenerational mentoring program can reduces vulnerability to respiratory virus infections (COVID, influenzas, colds), increase antiviral immune activity (Type I interferon responses), and reduce inflammatory immune activity in older African-American women and men living in a socioeconomically disadvantaged urban community. Blood samples will also be collected to determine which biological factors are most important in protecting older African-Americans from respira…
Inclusion Criteria: * Participating in the GenX intergenerational mentoring program * All GenX mentors \> 50 years of age are eligible to participate in this research * GenX program participation requires: * Reside in neighborhood of GenX schools (South-Central Los Angeles) * Pass basic literacy and cognitive function tests Exclusion Criteria: * Any health condition that would put participant at risk by enrollment/participation
GenX trains older adults to collaborate with K-3rd grade teachers in mentoring high-need elementary school students in core reading and math skills.
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