Metabolism and Sleep Apnea Treatment
University of Miami
Summary
The purpose of this research study is to see if obstructive sleep apnea (OSA) is associated with abnormalities in fat metabolism. Through this research study, the Investigator will evaluate how fat is metabolized in people with and without sleep apnea, what substances the fat tissue releases, and how these substances might change the way the body uses energy and sugar.
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
Aim 1 Group: Inclusion criteria: * Age between 18-70 years * Ability to provide consent Exclusion criteria * Body Mass Index (BMI) \> 40 kg/m2 * Prevalent myocardial infarction, coronary revascularization, heart failure, and stroke * Type 1 or Type 2 diabetes mellitus * Current or prior use of PAP or oral appliance therapy for OSA * Use of oral corticosteroids * Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and/or congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary dise…
Interventions
- DevicePAP Therapy
Auto-PAP device (ResMed AirsenseTM Autoset) with a heated humidifier will be provided along with an appropriate mask and connecting hose for nightly use
- BehavioralLifestyle Counseling Intervention
Lifestyle intervention will include counseling on (a) education on nutrition and exercise; and (b) behavioral support for identifying lifestyle change strategies and problem-solving barriers to improve the regularity and duration of sleep. This will be conducted using brochures on weight loss and sleep hygiene
Location
- University of MiamiMiami, Florida