Acute and Chronic Impacts of Muscadine Wine Polyphenols on Cognition, Memory, Mood, and Anxiety in Adults Over 50 Years of Age
University of Florida
Summary
Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive performance and mood through regulating the HPA axis, alleviating inflammation and oxidative stress, and/or inhibiting monoamine oxidase activities
Description
Although the exact biological mechanisms for depression and Alzheimer's Disease are not fully understood, it's believed that they are caused by a combination of factors. An increasing amount of scientific research has proposed several possible pathophysiologies linking depression and AD. For example, increased production of pro-inflammatory cytokines in the nervous system, oxidative stress induced by chronic inflammation leads to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and disturbance in the brain-derived neurotrophic factor signal pathway. Polyphenol has been well reco…
Eligibility
- Age range
- 50–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Healthy * BMI (18.5-29.9) * Body weight ≥110 pounds Exclusion Criteria: * Pregnancy * Breast-feeding * Smokers * Diabetic * Heavy drinkers * Subjective but not clinically diagnosed cognitive impairment (Montreal cognitive assessment score \<26), * Inability to understand the cognitive function tasks * Intake of medication that might influence the outcome of the study (e.g. psychostimulant) * cannabis product user * Clinically diagnosed mental illnesses * Cardiovascular and neurological disorders * Uncontrolled hypertension
Interventions
- OtherMuscadine Wine Polyphenol
dealcoholized muscadine wine with alcohol content \<0.5% with addition of 50ppm of sodium metabisulfite for preservation
- OtherPlacebo
this placebo beverage is formulated with matching sugar and organic acid content to the muscadine wine polyphenol. Food coloring is added to match the color of the intervention. 50ppm of sodium metabisulfite for preservation
Location
- Food Science and human nutrition department at University of FloridaGainesville, Florida