Rare and Atypical Diabetes Network
University of South Florida
Summary
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: 1. Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. 2. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical diabetes. 3. Understand the pathophysiology of individuals and families with novel forms of rare and atypical forms of diabetes.
Description
RADIANT has three distinct stages. Stage 1: Stage 1 participants will complete a consent form and a questionnaire to determine the potential for having atypical forms of diabetes. Participants identified as potentially atypical based on questionnaire responses will be asked to provide a blood sample to test for islet autoantibodies and complete additional questionnaires. The RADIANT Adjudication Committee, which is comprised of a team of experts in diabetes, will assess the data collected in Stage 1 and select and prioritize participants to proceed to Stage 2 and 3 for Whole Genome Sequenci…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: The following criteria or phenotypes will be considered for suspecting "atypical" participants: * Type 2 diabetes diagnosed at a time when the individual was prepubertal or non-obese * Mendelian pattern, especially with early onset (\<18 years old) * Syndromic (multiple systems involved) * Lipodystrophic * Extremes of BMI * "Mitochondrial" characteristics (e.g., myopathy, hearing deficits) * Non-progressive * Rapidly progressive ("fulminant") * Low insulin requirements (\<0.5 u/kg/day) * Cyclical hyperglycemia with periods of remission * Lean persons with polycystic ovari…
Locations (13)
- University of Colorado- DenverAurora, Colorado
- University of ChicagoChicago, Illinois
- Indiana UniversityIndianapolis, Indiana
- University of MarylandBaltimore, Maryland
- Massachusetts General Hospital (MGH)Boston, Massachusetts
- University of MichiganAnn Arbor, Michigan