Mingtao Zhao
Obtain blood samples for generation and maintenance of induced pluripotent stem cells (iPSCs) and genomic/DNA sequencing for biomedical research that will improve the understanding and treatment of pediatric cardiovascular disease
Human induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cell which can be generated from easily accessible patient cells, such as peripheral blood mononuclear cells and skin fibroblasts. As iPSCs are epigenetically reprogrammed from somatic cells, they retain all genetic information of the affected patients, thus providing an ideal model for studying the contribution of genetic variation to pediatric cardiovascular disease. In addition, human iPSCs can be differentiated into cardiomyocytes, endothelial cells, smooth muscle cells and cardiac fibroblasts, which are major affe…
Inclusion Criteria: 1. The subjects must have the diagnosis of cardiovascular disease 2. The subject must have a syndrome associated with cardiovascular disease 3. The subject must be related to an individual in cohort 1 or 2 4. The subject is considered a control and does not fall into any of the other cohorts Exclusion Criteria: N/A
One time intravenous blood draw
Arctuva estimate
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