Therapeutic Mechanisms of Epidural Spinal Cord Stimulation
University of Alabama at Birmingham
Summary
The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).
Description
The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography). The Investigators will identify patients with chronic pain who are scheduled for SCS…
Eligibility
- Age range
- 18–89 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Male or Female, age 18-89 2. Chronic pain for more than 3 months 3. Willing to visit a research lab 4. Willing to undergo a blood draw 5. Able to provide written informed consent Exclusion Criteria 1. History of neurological disease (e.g., dementias, Parkinson's) 2. History of stroke 3. Current diagnosis of cancer 4. Subject is unwilling or unable to comply with the protocol
Interventions
- DevicePermanent Epidural Spinal Cord Stimulation
Permanent Spinal Cord Stimulation implanted in participants undergoing routine care for management of chronic neuropathic pain.
Location
- University of Alabama at BirminghamBirmingham, Alabama