Pediatric Germ Cell Tumors: Outcomes, Genomics and Epigenetics
Children's Oncology Group
Summary
A Non-Therapeutic Study that aims to establish a cohort of GCT survivors to understand short term and long-term adverse effects of treatment and to conduct molecular analyses to improve risk stratification.
Description
PRIMARY OBJECTIVES: I. Establish a survivorship cohort for pediatric and adolescent GCT comprised of participants from AEPI10N1 and APEC14B1 to assess short term and long-term adverse events associated with GCT treatment. II. Compare somatic variation by tumor histology to identify molecular signatures that improve prognostic risk stratification. III. Identify methylation patterns that predict poor clinical outcomes, including disease relapse and death. OUTLINE: Medical records from pediatric and adolescent Germ Cell Tumor (GCT) participants from AEPI10N1 and APEC14B1 will be used to obta…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: * Cases will be eligible for the study if they have a primary diagnosis of GCT including germinoma (ICCC code105 9060-9065), teratoma (9080-9084), embryonal carcinoma (9070-9072), yolk sac tumor (9071), choriocarcinoma (9100, 9103, 9104), and mixed GCT (9085, 9101, 9102, 9105) in all sites including the brain. * The patient must be enrolled on APEC14B1 with consent to future contact or enrolled in AEPI10N1 with consent for future contact (N=827). Patients enrolled in AEPI10N1 were recruited from ACCRN07. All patients must be registered with COG by a North American member i…
Interventions
- OtherQuestionnaire Administration
Questionnaire provide to participant's about their health and quality of life since treatment
- OtherTumor Specimen Collection
Tumor DNA requested from the Biopathology Center
- OtherGermline DNA Samples
Germline DNA specimens requested from the Biopathology Center or newly collected saliva
- ProcedureBlood Sample Collection
Collection and storing of serum/plasma
Location
- University of MinnesotaMinneapolis, Minnesota