Understanding the Early Natural History of Cerebral Palsy - A Prospective Cohort Study
Children's Hospital Medical Center, Cincinnati
Summary
The study will describe the natural history of cerebral palsy (CP) as children develop over the first 2 years of life.
Description
This study aims to describe the early natural history of cerebral palsy (CP) by mapping the development of infants with, or at-risk of CP, over the first two years of life. Infants will be assessed at regular intervals up to 24 months of age, across a variety of childhood development to provide the first comprehensive developmental trajectories of this group. In doing so, it will contribute to the existing knowledge of CP development to assist clinicians and therapists with accurate information on prognosis and provide targeted interventions early and at the 'just-right' challenge. Where indic…
Eligibility
- Age range
- 0–2 years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: * Infants will be included if they have a diagnosis of CP or "at high risk of CP" and under the age of 12 months. * Infants at high risk of CP as defined by any two (any combination) of the following: 1. Neuroimaging predictive of a motor disability including the involvement of 1 or more of the following structures: sensori-motor cortex, Basal Ganglia, Posterior Limb of the Internal Capsule, pyramids. 2. Trajectory of cramped synchronized general movements (GMs) on General Movement Assessment (GMA) OR absent fidgety GMs at fidgety age 3. Hammersmith Infant Neurologi…
Location
- Cincinnati Children's Hospital Medical CenterCincinnati, Ohio