Decolonization to Reduce After-Surgery Events of Surgical Site Infection
University of California, Irvine
Summary
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * 18 years of age or older * Recent open (not solely laparoscopic) surgery involving an abdominal incision within the past 14 days. For cesarean section, recruitment restricted to BMI ≥ 40. * Able to communicate regularly by phone * Able to bathe, shower or have this task performed by a caregiver Exclusion Criteria: * Transfer to an acute care hospital * Discharged to receive end-of-life hospice measures * Discharged more than 14 days after surgery * Allergic to mupirocin and/or chlorhexidine * Active infection at enrollment\* \*Refers to 1. Infections requiring sys…
Interventions
- Drug4% Chlorhexidine Gluconate
Used for daily showering/bathing for 30 days after hospital discharge.
- Drug2% Mupirocin
Applied to each nostril twice daily for five days for the first two weeks after hospital discharge.
- DrugSoap Without Antiseptic Properties (Placebo)
Used for daily showering/bathing for 30 days after hospital discharge.
- DrugPlacebo Nasal Ointment
Applied to each nostril twice daily for five days for the first two weeks after hospital discharge.
Locations (4)
- Hoag Memorial Hospital PresbyterianNewport Beach, California
- University of California, Irvine Medical CenterOrange, California
- University of California, Davis Medical CenterSacramento, California
- University of California, San Francisco Medical CenterSan Francisco, California