Hypoxia and Heart Rate Variability
University of Miami
Summary
The purpose of this study is to evaluate how variations in oxygen demands may change heart electrical activity in individuals with and without oxygen dependence.
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
Healthy Participants Inclusion Criteria: • Ability to provide consent Exclusion Criteria: * BMI \> 40 kg/m2 * Prevalent myocardial infarction, coronary revascularization, heart failure, and stroke * Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and/or congestive heart failure, uncontrolled blood pressure or resistant hypertension, cancer, and active psychiatric disease (e.g., major depression) Nocturnal Hypoxemia Inclusion Criteria: * Ability to provide consent * Chronic respiratory condition resting Sat \< 95% off oxygen Exclusio…
Interventions
- OtherNocturnal Oxygen
Nocturnal oxygen will be increased hourly for a period of four hours up to 4 liters per minute (LPM). If the oxygen saturation (SpO2) falls below 70% the oxygen rate will be increased until patients achieve the threshold of 70% and then will proceed with titrations of 1 liter per minute LPM per hour.
Location
- University of MiamiMiami, Florida