Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps
Dartmouth-Hitchcock Medical Center
Summary
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.
Description
Colon polyps are common among adults ≥50 years and people with colon polyps are recommended to undergo regular follow-up colonoscopy (surveillance) in hopes of preventing subsequent colorectal cancer (CRC). Older adults, particularly those who are age ≥70 years, most of whom have a history of only small colon polyps, may benefit little from repeated colonoscopies because of the increased risks of colonoscopy due to age and co-morbidities and potentially limited life expectancy due to other competing medical problems - CRC may never be a problem for them. Older adults may also be hesitant to ge…
Eligibility
- Age range
- 65–82 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * English or Spanish speaking * Personal history of colorectal polyps * Most recent colonoscopy with ≤2 non-advanced polyps * Currently due or coming due within 12 months for colonoscopy * Able to provide written informed consent Exclusion Criteria: * Personal history of colorectal cancer * Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome) * Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease) * Most recent colo…
Interventions
- Diagnostic TestFIT
Annual FIT
- Diagnostic TestColonoscopy
One time surveillance colonoscopy
Locations (22)
- University of Alabama BirminghamBirmingham, Alabama
- University of ArizonaTucson, Arizona
- Jennifer Moreno Department of Veterans Affairs Medical CneterSan Diego, California
- Kaiser Permanente Northern CaliforniaWalnut Creek, California
- University of ColoradoAurora, Colorado
- MedStar HealthWashington D.C., District of Columbia