University of Southern California
The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease across the full disease spectrum. Building on the success of ADNI1, ADNI-GO, ADNI2, and ADNI3, ADNI4 integrates clinical, cognitive, imaging, genetic, and fluid biomarker data to characterize disease progression and predict cognitive decline. ADNI4 includes both in-clinic and remote cohorts and a small complementary sub-cohort, Together Exploring Aging Minds (TEAM-ADNI), which evaluates community-based recruitment and longitudinal data collection approaches.
Since its launch in 2004, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been a landmark public-private partnership focused on developing and validating biomarkers for Alzheimer's disease (AD) and improving clinical trial design. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2, and ADNI3 studies and integrates clinical, cognitive, imaging, genetic, and biochemical biomarker data to characterize the full spectrum of Alzheimer's disease, from normal cognition through dementia. The ADNI4 study is a multi-center, non-randomized, longitudinal, natural history, non-treatment…
Inclusion Criteria for Newly Enrolled Participants, CN Cohort: 1. Participant may or may not have a significant subjective memory concern as reported by participant, study partner, or clinician. 2. Normal memory function documented by scoring above demographically-adjusted cutoffs on the Logical Memory II subscale (Delayed Paragraph Recall, Paragraph A only) from the Wechsler Memory Scale - Revised (the maximum score is 25): 1. ≥9 for 16 or more years of education 2. ≥ 5 for 8-15 years of education 3. ≥ 3 for 0-7 years of education 4. Note: cut-offs may be modified over time as t…
Amyloid PET imaging with Florbetaben (Neuraceq) injection
Amyloid PET imaging with Amyvid (Florbetapir) injection
Tau PET imaging with Tauvid (Flortaucipir) injection
Tau PET imaging with MK-6240 injection
Amyloid PET imaging with NAV4694 injection
Tau PET imaging with PI-2620 injection