Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)
Columbia University
Summary
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.
Description
Adolescent major depressive disorder (MDD) is common and debilitating. Presently, gold-standard treatments are only effective for approximately half of patients, underscoring the need to develop novel interventions, particularly to target core underlying mechanisms and more effectively treat this recurrent disorder. Rumination, the tendency to perseverate about depressive symptoms, contributes to MDD onset and predicts treatment non-response and relapse. At the neural level, rumination is characterized by elevated functional connectivity within the default mode network (DMN), and similarly, p…
Eligibility
- Age range
- 13–18 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Ages 13-18 years-old * Written informed assent/consent and parental/guardian permission for 13-17 year-olds or informed consent for 18 year-olds * Tanner puberty stage ≥3 * Meets current diagnostic criteria for MDD * English fluency Exclusion Criteria: * Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders * Substance use disorder, moderate or severe in past 6 months * Active suicidal ideation with a specific plan * H…
Interventions
- OtherMindfulness + fMRI Neurofeedback
Prior to neurofeedback, participants will receive 45 minutes of mindfulness training. Participants will then receive mindfulness-based fMRI neurofeedback targeting the default mode network and frontoparietal control network.
Locations (2)
- Northeastern UniversityBoston, Massachusetts
- Columbia University Irving Medical CenterNew York, New York