Pediatric POTS: Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
Virginia Commonwealth University
Summary
This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains communicate.
Eligibility
- Age range
- 12–21 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Females 12-21 years old * Able to communicate and provide consent/assent * English speaking * Diagnosed with POTS (POTS will be defined standardly as a symptomatic ≥ 40 bpm rise in heart rate without a drop in blood pressure and with symptoms of orthostatic intolerance clinically) * Age-matched healthy control subjects: no POTS or other neurological disorders Exclusion Criteria: * Inflammatory arthritis, connective tissue or auto-immune disorder * Any chronic neurological disorder besides POTS * Evidence of unstable medical disorder, such as kidney (rising creatinine,…
Interventions
- BehavioralLooming task
Participants will be asked to look at some pictures during an fMRI scan. Participants will press a button as soon as they see the image appear.
Location
- Virginia Commonwealth UniversityRichmond, Virginia