University of California (UC), Davis Dietary Biomarkers Development Center
University of California, Davis
Summary
The purpose of this research is to find a set of markers in the blood and/or urine that can be linked to consumption of specific fruits and vegetables. This will allow for better understanding of the link between diet and health-related outcomes. Furthermore, the results of this study will lead to the development of new methods to evaluate the nutritional status of individuals in both community and clinical settings. Food frequency questionnaires and diaries/recalls can be affected by intentional or unintentional misreporting, and thus can create errors in determining nutritional status. This study will lead to the development of an objective way to assess the consumption of specific fruits and vegetables by the general population.
Description
The purpose of this research is to find a set of markers in the blood and/or urine that can be linked to consumption of specific fruits and vegetables. This will allow for better understanding of the link between diet and health-related outcomes. Furthermore, the results of this study will lead to the development of new methods to evaluate the nutritional status of individuals in both community and clinical settings. Food frequency questionnaires and diaries/recalls can be affected by intentional or unintentional misreporting, and thus can create errors in determining nutritional status. This…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Body Mass Index (BMI) 18.5-39.9 kg/m\^2 * Willingness to provide urine and have blood drawn Exclusion Criteria: * Pregnancy or lactation * Allergy or aversion to foods provided in test diet * History of gastrointestinal disorders including the following: 1. Ulcerative colitis or Crohn's disease 2. Celiac sprue 3. Hereditary non-polyposis colorectal cancer (HNPCC) 4. Familial adenomatous polyposis 5. Pancreatic disease 6. Liver disease * Previous gastrointestinal resection or bariatric surgery * Bleeding disorders that preclude blood draws * Recent hospital…
Interventions
- OtherAim 1 Meal Challenge 1
A meal challenge will be provided that contains 1 serving of peaches and 2 servings of strawberries as a smoothie and 2 servings of tomatoes and 1 serving of carrot as a vegetable dish.
- OtherAim 1 Meal Challenge 2
A meal challenge will be provided that contains 1 serving of banana and 2 servings of peaches as a smoothie and 1 serving of tomatoes and 2 servings of green beans as a vegetable dish.
- OtherAim 1 Meal Challenge 3
A meal challenge will be provided that contains 2 serving of bananas and 1 serving of strawberries as a smoothie and 1 serving of green beans and 2 servings of carrots as a vegetable dish.
- OtherAim 2 Typical American Diet
The diet will provide sufficient calories for weight maintenance and will contain refined grains and low amounts of fruits and vegetables, representative of the typical American diet. No bananas, strawberries, peaches, green beans, carrots, or tomatoes will be provided.
- OtherAim 2 Typical American Diet Plus Test Foods
This diet will provide sufficient calories for weight maintenance and will contain refined grains and low amounts of fruits and vegetables, representative of the typical American diet. Bananas, strawberries, peaches, green beans, carrots, and tomatoes will be provided in amounts less than or equal to 1 serving per day each.
Location
- USDA ARS Western Human Nutrition Research CenterDavis, California