Pharmacodynamics, Pharmacogenetics, Clinical Efficacy and Safety of Tradipitant for Functional Dyspepsia

Xiao Jing (Iris) Wang

Summary

To evaluate the effects of tradipitant relative to placebo on gastric motor functions, satiation, and postprandial symptoms in patients with functional dyspepsia.

Eligibility

Age range: 18–70 years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * Able to provide written consent * Body Mass Index (BMI) of 18-35 kg/m2 * Absence of other diseases which could interfere with interpretation of study results Exclusion Criteria: * Current H. pylori infection * Pregnancy or nursing * Recent history of Alcohol Use Disorder or Substance Use Disorder

Interventions

Drug
Tradipitant
Tradipitant Capsule
Drug
Placebo
Placebo Capsule

Location

Mayo Clinic in Minnesota
Rochester, Minnesota