Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
Columbia University
Summary
The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.
Description
Following informed consent, participants will undergo tests for heart health, physical function, memory testing, and brain structure and function using imaging (taking pictures of the brain with an MRI). Following these tests participants are randomized to a home-based walking program or health education for 6 months. Participants are given a fitness tracker and gets ongoing telephone coaching during the 6 months. After 6 months the tests are repeated.
Eligibility
- Age range
- 55+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * • Diagnosed stage 3-4 chronic kidney disease (CKD, estimated glomerular filtration rate (eGFR) \<60 to 20 ml/min); * \>55 yrs of age * Mild cognitive impairment (18-26 on the MOCA) * ability to undergo an MR * no history of major head trauma (No head trauma/concussion with loss of consciousness) * Speaks, reads, writes English Exclusion Criteria: * • Diagnosed Dementia or a Clinical Dementia Rating Scale score of \<2, or a MOCA of \<18 * Participating in a supervised exercise program with intent to increase fitness levels 3 days/week, * Requires assisti…
Interventions
- BehavioralHome-based walking exercise
A 6-month partially supervised walking exercise program using a tapered approach.Participants will begin exercise (walking) at a relatively low intensity and progress to moderate intensity. Intensity will start at 40% and progress as tolerated up to 60-70%. Rating of perceived exertion of 12-14 (fairly light to moderate) will be used to aid intensity (Rating of perceived exertion 6-20 scale). This is an accepted method for achieving desired exercise intensity. Participants will progress over time to exercise 3-4/week for 30-45 minutes. The exercise program may need to be adjusted for (e.g. 10 minutes of exercise 3 times), to achieve the minimum exercise dose of 30 minutes. This will be determined for each individual participants as needed.
- OtherAttention control
Health education and stretching
Location
- Columbia UniversityNew York, New York