University of Alabama at Birmingham
The purpose of this study is to evaluate the effects on folic acid supplementation in a population living in an environment with chronic arsenic exposure in Birmingham, Alabama.
Folic acid supplementation effects urinary arsenic excretion. In this project investigators propose to investigate if oral folic acid dietary supplementation can increase urinary arsenic metabolite excretion
Inclusion Criteria: * ≥18 years of age * Resident of the superfund site * Clinically stable with no significant changes in general health status in the past 4 weeks prior to screening as assessed by the investigator * Provide written informed consent Exclusion Criteria: * Pregnancy * Ongoing folic acid nutritional supplementation * Methotrexate use * Megaloblastic anemia * Alcoholic liver disease * Malabsorptive syndromes - celiac disease, inflammatory bowel disease
Folic acid supplementation to assess for increased arsenic metabolite excretion
Placebo group to assess arsenic metabolite excretion
Arctuva estimate
Actual pay is set by the research site.
Verify or correct the compensation shown for this listing.