Weill Medical College of Cornell University
The investigators hypothesize that there would be significant changes in blood pressure or heart rate in patients consuming caffeine while taking terbinafine.
Terbinafine is a common oral medication used for moderate to severe nail onychomycosis. On the terbinafine package insert, it states that terbinafine can reduce clearance of caffeine by 19%. However, the clinical effects of this finding in patients have yet to really be studied. Decreased clearance of caffeine can physically present with measurable signs such as an increased blood pressure or increased heart rate, as well as less measurable symptoms of GI upset, irritability, headache, insomnia. As a result, dermatologists do not always know how to counsel patients taking terbinafine on their…
Inclusion Criteria: * Patient of any gender at least 18 years of age * Diagnosed with onychomycosis * Planning to start oral terbinafine Exclusion Criteria: * Pregnant or breastfeeding * Any history of anxiety or hypertension * Any patient with an inability to give consent
Subjects would be randomized to a group "Caffeinated" and subjects will be 95 mg of caffeine in caffeinated coffee.
Subjects would be randomized to a group "Decaffeinated" and subjects will be no caffeine in decaffeinated coffee.
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