Tissue Destruction and Healing in Celiac Disease
University of Chicago
Summary
The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of tissue destruction and its ability to heal in individuals with celiac disease. Information collected in the study will help researchers to generate better resources to advance celiac disease patient care.
Description
Celiac disease is an autoimmune enteropathy characterized by chronic inflammation of the small intestinal mucosa triggered by gluten uptake that occurs in genetically susceptible individuals carrying the specific class II human leucocyte antigens (HLA) DQ2 and DQ8 alleles. There is a spectrum in intestinal tissue damage associated with celiac disease. Some individuals develop inflammatory immunity in the absence of tissue damage, while others experience tissue damage ranging from partial to total villous atrophy. Persistent mucosal damage is associated with several severe complications, includ…
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Gluten challenge group: 1. Age 18 to 75 years old 2. Diagnosis of Celiac disease for at least 12 months by intestinal biopsy 3. Follow a strict gluten-free diet for at least the 12 consecutive months Gluten de-challenge group: 1. Age 18 to 75 years old 2. Showing typical celiac disease symptoms 3. Not on a gluten-free diet Control group: 1. Age 18 to 75 years old 2. Females who are not pregnant Exclusion Criteria: Gluten challenge group: 1. Diagnosis of any severe complication of celiac disease 2. Diagnosis of other chronic, active GI disease 3. Selective IgA defic…
Interventions
- Dietary SupplementGluten containing snack bar
Ingest snack bars containing 3 grams of gluten every day for 6 weeks.
Locations (3)
- California Institute of TechnologyPasadena, California
- The University of ChicagoChicago, Illinois
- Mayo ClinicRochester, Minnesota