Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations
H. Lee Moffitt Cancer Center and Research Institute
Summary
This study will evaluate obesity-mediated mechanisms of pancreatic carcinogenesis in minority populations.
Description
This observational study will evaluate obesity-mediated mechanisms of pancreatic carcinogenesis in minority populations consisting of adult males or females, 18 years of age or older, who self-report as African American (AA) or Non-Hispanic White (NHW), and present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor. This study will also include patients who have been previously recruited as part of the FPC study. Ou…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults 18 years of age or older at time of signing informed consent * Patients who self-report as African American, Non-Hispanic White * Patients who present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or the University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor. Exclusion Criteria: * Patient under 18 years of age * Has no suspicion or diagnosis of a pancreatic cancer or tumor * Self-reported race/ethnicity other than African American or No…
Interventions
- OtherBlood Sample Collection
Participants will have 40 mL of blood drawn at baseline/pre-treatment. The study team will aim to have this blood collected at the time of standard of care blood draw if possible.
- OtherTissue Sample Collection
At the time of tissue biopsy or surgical resection (if applicable) pancreatic tumor tissue, fat, tissue from site of metastasis, and cyst fluid (if applicable) will be collected.
- OtherData Collection
Participants will complete a study questionnaire at baseline that includes medical history, lifestyle, and family history information.
- OtherMedical Image Collection
Medical images that are obtained during routine care such as computed tomography (CT) scans, magnetic resonance imaging (MRIs) and ultrasounds will be reviewed by the study team throughout the participant's medical care.
Locations (2)
- Moffitt Cancer CenterTampa, Florida
- University of Mississippi Medical CenterJackson, Mississippi