Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms
University of Illinois at Urbana-Champaign
Summary
The study will employ a combined laboratory-ambulatory design. Participants will engage in ambulatory assessment over the course of 14 days, wearing biosensors assessing transdermal alcohol concentration (TAC) and providing breathalyzer readings in real-world contexts. Also during this period, participants will attend three laboratory alcohol-administration sessions scheduled at one-week intervals, with alcohol dose and rate of consumption manipulated within and between participants, respectively. Laboratory visits will also double as ambulatory orientation, check-in, and close-out sessions.
Description
Laboratory Procedures: The aim of the laboratory study is to capture variability in the TAC-BAC relationship across individuals in a controlled context, featuring manipulations theorized to confound transdermal measurements of BAC and so ensuring adequate variability in these factors in the broader dataset. Laboratory alcohol-administration sessions will be held at one-week intervals, scheduled at study initiation (day 0), study midpoint (day 7), and study end (day 14). Alcohol-administration procedures will employ a within (alcohol dose) X between (rate of consumption) participant design. Al…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 21 years or older * drink alcohol at least 2x weekly Exclusion Criteria: * psychological or medical conditions that might contraindicate alcohol-administration * history of adverse reaction to type and amount of beverage used in the study * currently seeking treatment for alcohol use disorder * does not drink alcohol regularly * taking drugs or medications for which alcohol consumption would be contraindicated * women who are pregnant or are attempting to become pregnant
Interventions
- DrugAlcohol
Alcohol administered orally at multiple doses and consumption speeds to test transdermal device accuracy
Location
- University of Illinois at Urbana-ChampaignChampaign, Illinois