University of California, San Francisco
This is a randomized controlled trial comparing density gradient centrifugation and microfluidic sperm sorting in patients undergoing intrauterine insemination to evaluate cumulative pregnancy outcomes.
Study participants will be randomized to either standard sperm preparation (density gradient centrifugation) versus sperm preparation with the Zymot Multi sperm preparation device for their three month intrauterine insemination treatment course. Patients will follow standard treatment plans designed by their fertility physician and will be followed until referred for prenatal care at 8-10 weeks of pregnancy to determine pregnancy outcomes.
Inclusion Criteria: * Patients undergoing intrauterine insemination * Patient assigned female at birth with age \<41 Exclusion Criteria: * Any significant disease or psychiatric disorder that would interfere with the consenting process * Prior intrauterine insemination * Use of frozen donor sperm * Non-English speaker
Sperm preparation with Zymot Multi sperm preparation device
Sperm preparation with density gradient centrifugation
Arctuva estimate
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