Mayo Clinic
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
Inclusion Criteria: * For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography * For controls: no cardiac disease history Exclusion Criteria: * Pregnancy * Known or suspected unstable cardiac condition within 4 weeks of the study * Active treatment with anticoagulation or dual antiplatelet therapy * Prisoner
We will measure arterial stiffness using arterial tonometry.
We will collect limited ultrasound images of the heart.
We will perform ultrasound imaging of the carotid artery.
We will measure the elastic properties of the arteries using elastography.
We will measure the ankle-brachial index to assess peripheral artery blood flow.
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
Arctuva estimate
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