Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
Mayo Clinic
Summary
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography * For controls: no cardiac disease history Exclusion Criteria: * Pregnancy * Known or suspected unstable cardiac condition within 4 weeks of the study * Active treatment with anticoagulation or dual antiplatelet therapy * Prisoner
Interventions
- OtherArterial Tonometry
We will measure arterial stiffness using arterial tonometry.
- Diagnostic TestEchocardiogram
We will collect limited ultrasound images of the heart.
- Diagnostic TestCarotid Ultrasounds
We will perform ultrasound imaging of the carotid artery.
- Diagnostic TestElastography
We will measure the elastic properties of the arteries using elastography.
- OtherAnkle-Brachial Index
We will measure the ankle-brachial index to assess peripheral artery blood flow.
- OtherMicroneurography with sympathoexcitatory maneuvers
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
Location
- Mayo Clinic RochesterRochester, Minnesota