Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Wake Forest University Health Sciences
Summary
The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers
Description
The FDA is planning regulatory actions to limit nicotine levels in cigarettes as far as it is not reduced to zero. The strategy is designed to reduce the addictiveness of cigarettes. However, nicotine related effects of the cigarettes with reduced nicotine content on various body systems are largely unknown. Following formal implementation of the regulatory policy what cardiovascular effects of reduced nicotine cigarettes, also called very low nicotine content cigarettes (VLNCC) are expected to persist is important to determine. This study will determine the cardiovascular effects of VLNCC suc…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Self-reported cigarette smoking at least once in the past 30 days * ≥21 years old * Willingness to smoke research cigarettes or usual brand cigarettes during lab visit. * Ability to speak, comprehend, and read English sufficiently to complete study procedures Exclusion Criteria: * Self-reported diagnosis of cardiovascular diseases like coronary artery disease, stroke, peripheral artery disease, cardiac arrhythmia, pulmonary embolism \& blood clots in legs and arm in the past 3 months * Body temperature ≥ 100.4˙F * Unstable health conditions interfering with electrocard…
Interventions
- DrugSPECTRUM cigarettes
SPECTRUM cigarettes have varying amount of nicotine content
- Otherusual brand of Cigarettes
Usual Brand of Cigarettes
Location
- Wake Forest University Health SciencesWinston-Salem, North Carolina