University of Pennsylvania
The goal of this observational study is to learn about changes in the brain of patients over the first 3 years following a traumatic brain injury (TBI). The main question it aims to answer are: \- How TBI effect the rate of brain tissue loss compare to healthy brain Participants will give blood samples, complete MRI scans, and neuropsychological assessment measures. Researchers will compare results between healthy control group and TBI group to determine changes in injured brains.
Inclusion Criteria: 1. Age 18-65, inclusive 2. History of non-penetrating TBI of at least moderate severity (defined by evidence of trauma-related neuroimaging abnormality on cranial computerized tomography (CT) scan. 3. High-velocity, high-impact injury mechanism consistent with diffuse axonal injury (e.g., motor vehicle accident, fall from height, etc.) 4. Immediate loss of consciousness (cases with delayed loss of consciousness due to expanding lesions will be excluded) Exclusion Criteria: 1. History of premorbid disabling neurological or psychiatric disease (such as epilepsy, brain tumo…
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