Efficacy of a PrEP Uptake & Adherence Intervention Among Male Sex Workers Using a 2-stage Randomization Design
Brown University
Summary
"PrEPare for Work" is a randomized controlled trial (RCT) whose goal is to test the efficacy of a behavioral intervention (Short Title: PrEPare for Work) in improving PrEP uptake, adherence, and persistence among male sex workers (MSW)
Description
A theory-based, manualized intervention -called "PrEPare for Work"-includes two separate but complementary interventions that address MSW-specific behavioral, economic, interpersonal \& structural-level barriers to accessing and adhering to PrEP: 1) peer-led, strengths-based case management (SBCM) for PrEP linkage and uptake; and 2) a technology and counseling intervention to optimize PrEP adherence (once they have access to PrEP). This research will test the PrEPare for Work intervention in a fully-powered RCT to assess efficacy and cost-effectiveness.
Eligibility
- Age range
- 18+ years
- Sex
- Male
- Healthy volunteers
- Yes
Inclusion * Age: 18 years or older * Assigned male sex at birth * Identifies as male at enrollment * Report having engaged in condomless anal sex with another man in the past 3 months * Report having exchanged sex for money, drugs, items of value, or a place to stay with another man in the past 3 months * Report HIV status as negative or unsure * Not currently on PrEP * Able to understand and speak English or Spanish Exclusion * Unable to provide informed consent due to severe mental or physical illness, cognitive impairment, or substance intoxication at the time of interview (will use an a…
Interventions
- BehavioralStage 1 Strength Based Case Management (SBCM) Condition
Intervention participants will receive a trained SBCM to motivate, support, and assist in linkage to PrEP prescribers to help facilitate obtaining PrEP medication to initiate treatment.
- BehavioralStage 2 PrEPare for Work Intervention Condition
Intervention participants will receive 1-on-1 adherence counseling and personalized daily text messaging reminders to increase PrEP adherence. Intervention participants will undergo three adherence intervention sessions (once per week for 3 weeks) with interventionist.
Locations (5)
- UCLA Fielding School of Public HealthLos Angeles, California
- The Miriam HospitalProvidence, Rhode Island
- Open Door HealthProvidence, Rhode Island
- Project Weber/RENEWProvidence, Rhode Island
- Brown University School of Public HealthProvidence, Rhode Island